Stanniocalcin-1: A Model for Evaluating Rescue of Photoreceptor Degeneration in the Rhodopsin Transgenic Pig
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چکیده
Purpose: To assess the histologic rescue of photoreceptors with stannocalcin-1 (STC-1) protein therapy in an in vivo porcine model of retinal degeneration. To assess the functional therapeutic efficacy of stannocalcin-1 (STC-1) protein therapy on the rescue of photoreceptors in an in vivo porcine model of retinal degeneration. To test the hypotheses that STC-1 improves the expression of photoreceptorspecific gene transcripts, increases the expression of UCP-2, and decreases the levels of two protein adducts generated by reactive oxygen species in the retina.
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تاریخ انتشار 2014